RecruitingOsteoarthritis · Overweight and Obesity
Study for People With Excess Body Weight and Knee Osteoarthritis
Montreal, Quebec
Osteoarthritis is the most common form of arthritis in Canada. It affects the whole joint: the cartilage that cushions the ends of the bones, the bone underneath, and the muscles and ligaments that support it. Over time the joint can become painful and stiff, and everyday things like stairs, walking or gripping a jar can get harder.
Osteoarthritis is often described as wear and tear, but that is only part of the picture. Cartilage does thin with use, and the bone underneath and the soft tissues around the joint change as well. Past injuries, how much load a joint carries, muscle strength and family history all play a part, which is why two people the same age can have very different joints.
It is also not only a condition of later life. Arthritis Society Canada reports that more than half of Canadians living with osteoarthritis are younger than 65. The knees, hips, hands, feet and spine are affected most often, and it is common to have symptoms in more than one joint.
Symptoms vary from person to person and often change from day to day. Many people have long stretches where a joint feels manageable, then a flare that settles again.

Some risk factors cannot be changed:
Others can often be worked on, usually with support from a health care team:
Osteoarthritis is usually identified by a family doctor or nurse practitioner, based on how you describe the pain, how long it has lasted, and a physical examination of the joint. X-rays may be ordered to look at the joint and to help rule out other causes, and blood tests may be used to check for inflammatory types of arthritis. Some people are referred on to a rheumatologist, an orthopaedic surgeon or a physiotherapist for further assessment.
Clinical research for Osteoarthritis is enrolling. See the current studies
There is no treatment yet that repairs a joint already damaged by osteoarthritis. Care in Canada focuses on easing pain, keeping the joint moving and protecting your independence. Depending on your situation and what matters to you, a health care team may discuss:
What suits one person will not suit another. These are decisions for you and your own clinician, and this page is not a recommendation about any of them.
Nothing available today has been shown to stop or reverse the joint damage of osteoarthritis, so most care is aimed at symptoms rather than the disease itself. That gap is what osteoarthritis research is trying to close. Studies are currently evaluating candidate disease-modifying drugs aimed at cartilage and bone, antibodies and other agents that target pain-signalling pathways such as nerve growth factor, injectable and cell-based approaches, and non-opioid pain medicines. Others compare ways of delivering exercise and self-management support, including digital and remote programs, and look at how to help people whose pain persists after joint replacement.
Clinical studies are how any of these are tested. Taking part is voluntary, you give informed consent before anything begins, and you can stop at any time without affecting the care you get from your own doctor. Joining a study does not mean giving up your current treatment, and no one can tell in advance whether a study will help you personally.
This page is written in plain language for people considering clinical research. It is general health information, not medical advice, and it does not replace a conversation with your own doctor or nurse practitioner.
Age is the strongest risk factor, but osteoarthritis is not simply wear and tear. It involves changes in cartilage, in the bone underneath and in the soft tissues around the joint, and it is influenced by past injuries, body weight, joint loading and family history. More than half of Canadians living with osteoarthritis are younger than 65.
Many people worry about this. Exercise therapy is a standard part of osteoarthritis care in Canada and is often delivered through physiotherapy or programs such as GLA:D Canada. A physiotherapist can help you choose activities and a pace that suit your joints. Talk with your health care provider before starting something new, especially if a joint is very painful or swollen.
Studies are how researchers learn whether new medicines, injections, devices or exercise and self-management programs actually help, and how they compare with current care. Taking part usually means extra assessments and close monitoring by a research team. Participation is voluntary, you give informed consent first, and you can withdraw at any time without affecting your regular care.
RecruitingOsteoarthritis · Overweight and Obesity
Montreal, Quebec
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