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Study for People With Excess Body Weight and Knee Osteoarthritis

Enrolling at: Montreal
Phase 3Study phase
18+Age range
1 siteResearch locations

About this study

Are you Struggling With Obesity and Knee Pain Caused by Osteoarthritis?

This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Would you like to take part?

As a volunteer in a research study, you’ll receive study-related medical care from the study doctor and regular follow-up of your health to monitor the effectiveness of the care you’ll receive. The results of this research will be used to find out if the investigational medication being studied will be of benefit to others struggling with obesity and osteoarthritis related pain, and whether it will be made widely available to all Canadians trying to manage these conditions. Study volunteers are an important part of moving medical care forward.

Who may qualify

You may qualify if
  • Are male or female (sex at birth)
  • Are age 18 years or above at the time of signing the informed consent
  • Have a clinical diagnosis of knee osteoarthritis (OA) (American College of Rheumatology criteria) with radiographic changes (Kellgren Lawrence [KL] grades 2 to 4 as per central reading) in target knee. Target knee joint is defined as most symptomatic knee at screening. If pain in knees is equal, the target knee joint will be the dominant leg
  • Have symptomatic knee OA with first appearance of pain in the target knee > 90 days prior to screening and pain in the target knee for > 15 days over the prior 30 days
  • Have a willingness to complete a 72-hour washout period of analgesics before all visits involving WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC) questionnaire (acetaminophen 4 grams (g)/day is allowed as rescue medication up until 24 hours before those visits)
This study may not be a fit if
  • Have glycated haemoglobin (HbA1c) ≥ 6.5% (48 mmol/mol) as measured by the central laboratory at screening
  • Have a history of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records
  • Have received treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening
  • Have any joint prosthesis or joint replacement in target knee
  • Have had arthroscopy or injections into target knee within the last 90 days prior to screening
  • Have any other joint disease in target knee including gout and pseudogout
Every study has additional criteria the research site will review with you.

What participation may involve

  • Regular visits with the study team at no cost
  • Study assessments and health monitoring throughout
  • Check-ins between visits
  • Informed consent before anything begins — questions welcome

What participants may receive

  • Study-related care from a physician-led team
  • Study assessments at no cost
  • Reimbursement for reasonable travel, where applicable
Specifics vary by study and site, and are never a guarantee of benefit. Being in a study is not a substitute for regular medical care.
Participating research sites

Where this study is enrolling

MONTREAL, QCCentre Medical AcadiePrincipal investigator: Dr. Ronald AkhrasView site →

Learn more

About the condition

General Health

General health is the part of clinical research that is not built around a single diagnosis: prevention, vaccines, healthy ageing, weight and smoking, and studies that need volunteers…

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About the condition

Osteoarthritis

Osteoarthritis is the most common form of arthritis in Canada. It affects the whole joint: the cartilage that cushions the ends of the bones, the bone underneath, and…

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About the condition

Weight Conditions (Overweight, Obesity)

Obesity is a long-term medical condition in which extra body fat builds up to a point where it can affect health. Canadian clinical guidelines describe it as a…

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About the condition

Arthritis & Chronic Pain

Arthritis is not one condition but a group of more than 100, all affecting joints and the tissues around them. Chronic pain means pain that lasts longer than…

Learn about this condition →
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Common questions

Do I have to decide now?
No. Answering the questions is not a commitment — it simply lets the research team see whether this study may be appropriate and contact you to talk it through.
Will it cost me anything?
No. Study visits and study assessments are provided at no cost, and reasonable travel may be reimbursed where applicable.
What happens after I submit the form?
A member of the research team reviews your answers and contacts you — usually within two business days — to answer questions and review the next steps.
Could I receive a placebo?
Some studies compare a treatment with a placebo. Whether this study does is explained clearly during informed consent, before you decide anything.
Can I leave the study after it starts?
Yes. Participation is always voluntary. You can withdraw at any time without giving a reason and without it affecting your regular medical care.
Request contact

Ask the research site to contact you

Your answers go only to the research site, help the team prepare before they call — and completing the form doesn’t obligate you to take part.
JAS Study Interest (Stream A)

See if you may qualify

A few quick questions — about a minute. Your answers help the research team prepare before they contact you.

For anyone under 18, a parent or legal guardian should complete this form and would need to consent on their behalf.

See if you may qualify →

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