HPV Vaccine Study for Women 16 to 26

About this study

Are you interested in advancing research on women’s health?

Researchers are looking for new ways to prevent cancers related to human papillomavirus (HPV). HPV is a common virus that can cause infection. There are many different types of HPV.

A standard vaccine to prevent HPV-related cancers is V503. V503 protects against 9 types of HPV. V540A is a study vaccine designed to protect against the same (shared) 9 HPV types plus other (unique) HPV types.

Researchers want to learn if V540A:

Is safe and if people tolerate it
Works as well as V503 to cause an immune response (the body’s response to protect against infections and illnesses) to the shared HPV types.

Would you like to take part?

As a volunteer in a research study, you’ll receive study-related medical care from the study doctor and regular follow-up of your health to monitor the effectiveness of the care you’ll receive. The results of this research will be used to find out if the investigational medication being studied will be of benefit to other women at risk of contracting HPV, and whether it will be made widely available to all Canadian women trying to manage this condition. Study volunteers are an important part of moving medical care forward.

Who may qualify

You may qualify if

Are in good health
Have a lifetime history of 0 to 4 sexual partners of any sex/gender
Are a participant assigned female sex at birth, and are not breastfeeding during the study intervention period and for at least 30 days after the last dose of study intervention

This study may not be a fit if

Have a history of severe allergic reaction (e.g., swelling of the mouth and throat, difficulty breathing, hypotension, or shock) that has required medical intervention
Have a known history of functional or anatomic asplenia
Are currently immunocompromised or have been diagnosed as having congenital or acquired immunodeficiency, human immunodeficiency virus infection, lymphoma, leukemia, systemic lupus erythematosus, rheumatoid arthritis, juvenile rheumatoid arthritis, inflammatory bowel disease, or other autoimmune condition
Have thrombocytopenia or other coagulation disorders
Have had a positive test for human papillomavirus (HPV)
Have a history of recurrent respiratory papillomatosis or HPV-related head and neck cancer, or HPV-related anal lesions or anal cancer
Have a history of an abnormal cervical biopsy result
Have a history of HPV-related external genital lesions or external genital cancer, HPV-related vaginal lesions or vaginal cancer
Have received a dose of any HPV vaccine before study entry
Have received within 12 months before the Day 1 vaccination, are receiving, or plan to receive during the study, immunosuppressive therapies or other therapy known to interfere with the immune response
Are currently receiving systemic steroid therapy or have received 2 or more courses of high-dose corticosteroids lasting at least 1 week in duration in the year prior to Day 1 vaccination
Have received within the 3 months before the Day 1 vaccination, is receiving, or plans to receive during the study any immune globulin product

Every study has additional criteria the research site will review with you.

What participation may involve

Regular visits with the study team at no cost
Study assessments and health monitoring throughout
Check-ins between visits
Informed consent before anything begins — questions welcome

Time commitment: ≈7 months — confirmed by the research site. The full visit schedule is explained during informed consent.

What participants may receive

Study-related care from a physician-led team
Study assessments at no cost
Reimbursement for reasonable travel, where applicable

Specifics vary by study and site, and are never a guarantee of benefit. Being in a study is not a substitute for regular medical care.

Participating research sites

Where this study is enrolling

TORONTO, ONAlbion Finch Medical CentrePrincipal investigator: Dr. Anil K. GuptaView site →

SARNIA, ONBluewater Clinical Research GroupPrincipal investigator: Dr. John O’Mahony, Dr. Sean PetersonView site →

Learn more

About the condition

Rotavirus

Rotavirus causes gastroenteritis, a gut infection, mainly in babies and young children. It brings watery diarrhoea and vomiting for several days. The risk is not the diarrhoea itself…

Learn about this condition →

About the condition

Women’s Health

Women's health covers conditions that affect only people with female reproductive anatomy, conditions that affect women more often or differently, and the care built around periods, contraception and…

Learn about this condition →

Other studies you can explore

All current studies →

RecruitingA Study for Intermittent Prevention of Menstrual MigraineSarniaCheck availability →

Common questions

Do I have to decide now?

No. Answering the questions is not a commitment — it simply lets the research team see whether this study may be appropriate and contact you to talk it through.

Will it cost me anything?

No. Study visits and study assessments are provided at no cost, and reasonable travel may be reimbursed where applicable.

What happens after I submit the form?

A member of the research team reviews your answers and contacts you — usually within two business days — to answer questions and review the next steps.

Could I receive a placebo?

Some studies compare a treatment with a placebo. Whether this study does is explained clearly during informed consent, before you decide anything.

Can I leave the study after it starts?

Yes. Participation is always voluntary. You can withdraw at any time without giving a reason and without it affecting your regular medical care.

Request contact

Ask the research site to contact you

Your answers go only to the research site, help the team prepare before they call — and completing the form doesn’t obligate you to take part.

JAS Study Interest (Stream A)

See if you may qualify

A few quick questions — about a minute. Your answers help the research team prepare before they contact you.

Who may take part in this study?

Myself

Someone I care for

Age of the person who may take part

For anyone under 18, a parent or legal guardian should complete this form and would need to consent on their behalf.

Has a doctor diagnosed you (or the person who may take part) with the condition this study is about?

Yes

Not sure

Postal code (first 3 characters are enough)

HPV Vaccine Research for Healthy Female Participants