Rheumatoid Arthritis Study, Windsor

About this study

Rheumatoid Arthritis (RA) is an autoimmune disorder that causes swollen and painful joints, particularly in the hands, feet, wrists and elbows. Other symptoms of RA include inflammation of the lungs and heart, as well as low red blood cell count. The cause of this disorder is not known for certain, but can be a result of differing genetic and environmental factors. RA affects between 0.5 to 1% of adults in the developed world.

Do you suffer from discomfort or pain caused by Rheumatoid Arthritis?

This study is designed to assess efficacy and safety of treatment with an experimental medication for 28 weeks. Participants will receive subcutaneous (SC) injection of one of three different doses of AZD1163 or placebo, along with Standard of Care until Week 24 followed by a safety follow-up (FU) period of 28 weeks.

Would you like to take part?

As a volunteer in a research study, you’ll receive study-related medical care from the study doctor and regular study-related follow up on your RA to monitor the effectiveness of the care you’ll receive. The results of this research will be used to determine whether or not the medication being studied will be of benefit to others with early RA. Study volunteers are an important part of moving medical care forward.

Who may qualify

You may qualify if

Have been diagnosed with adult-onset RA as defined by the 2010 ACR/EULAR classification criteria for at least 12 weeks prior to screening.
Have moderately-to-severely active RA as defined by: a. >= 6 swollen joints on 66SJC and >= 6 tender joints on 68TJC; b. CRP > upper limit of normal.
Have a positive ACPA at screening.
Have a history of inadequate response, or loss of response, or intolerance to:
- a. at least one csDMARD treatment, AND/OR
- b. At least one and at most 2 TNFi.
Have a history of at least 12 weeks treatment and >= 4 weeks stable on a csDMARD and/or SC TNFi prior to the day of randomization.

This study may not be a fit if

Have a history or evidence of an alternate autoimmune or other condition that could confound the diagnosis of RA. Participants with RA and secondary Sjogren’s disease are eligible.
Have received or are planning to receive any biologic DMARDs (except for TNFi) or targeted synthetic DMARDs.

Every study has additional criteria the research site will review with you.

What participation may involve

Regular visits with the study team at no cost
Study assessments and health monitoring throughout
Check-ins between visits
Informed consent before anything begins — questions welcome

What participants may receive

Study-related care from a physician-led team
Study assessments at no cost
Reimbursement for reasonable travel, where applicable

Specifics vary by study and site, and are never a guarantee of benefit. Being in a study is not a substitute for regular medical care.

Participating research sites

Where this study is enrolling

WINDSOR, ONWindsor Health CentrePrincipal investigator: Dr. Syed Anees, Dr. Sabeen AnwarView site →

Learn more

About the condition

Arthritis & Chronic Pain

Arthritis is not one condition but a group of more than 100, all affecting joints and the tissues around them. Chronic pain means pain that lasts longer than…

Learn about this condition →

About the condition

Rheumatoid Arthritis

Rheumatoid arthritis, often shortened to RA, is an autoimmune disease: the immune system attacks the lining of your joints instead of only defending you against infection. It usually…

Learn about this condition →

Other studies you can explore

All current studies →

RecruitingStudy for People With Excess Body Weight and Knee OsteoarthritisMontrealCheck availability →

RecruitingStudy for Participants With Osteoarthritis Knee Pain and ObesityToronto · StouffvilleCheck availability →

RecruitingA Study of Orforglipron in Participants With Obesity and OsteoarthritisSarnia · Hamilton · VictoriaCheck availability →

Common questions

Do I have to decide now?

No. Answering the questions is not a commitment — it simply lets the research team see whether this study may be appropriate and contact you to talk it through.

Will it cost me anything?

No. Study visits and study assessments are provided at no cost, and reasonable travel may be reimbursed where applicable.

What happens after I submit the form?

A member of the research team reviews your answers and contacts you — usually within two business days — to answer questions and review the next steps.

Could I receive a placebo?

Some studies compare a treatment with a placebo. Whether this study does is explained clearly during informed consent, before you decide anything.

Can I leave the study after it starts?

Yes. Participation is always voluntary. You can withdraw at any time without giving a reason and without it affecting your regular medical care.

Request contact

Ask the research site to contact you

Your answers go only to the research site, help the team prepare before they call — and completing the form doesn’t obligate you to take part.

JAS Study Interest (Stream A)

See if you may qualify

A few quick questions — about a minute. Your answers help the research team prepare before they contact you.

Who may take part in this study?

Myself

Someone I care for

Age of the person who may take part

For anyone under 18, a parent or legal guardian should complete this form and would need to consent on their behalf.

Has a doctor diagnosed you (or the person who may take part) with the condition this study is about?

Yes

Not sure

Postal code (first 3 characters are enough)

A Study in Participants With Rheumatoid Arthritis