Zilebesiran Blood Pressure Study

Q: Do I have to decide now?

No. Answering the questions is not a commitment - it simply lets the research team see whether this study may be appropriate and contact you to talk it through.

Q: Will it cost me anything?

No. Study visits and study assessments are provided at no cost, and reasonable travel may be reimbursed where applicable.

Q: What happens after I submit the form?

A member of the research team reviews your answers and contacts you - usually within two business days - to answer questions and review the next steps.

Q: Could I receive a placebo?

Some studies compare a treatment with a placebo. Whether this study does is explained clearly during informed consent, before you decide anything.

Q: Can I leave the study after it starts?

Yes. Participation is always voluntary. You can withdraw at any time without giving a reason and without it affecting your regular medical care.

About this study

Do you have Hypertension that is not adequately controlled and either established Cardiovascular Disease, or are at high risk for Cardiovascular Disease?

The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) events.

Would you like to take part? Would you like a friend or family member to take part?

As a volunteer in a research study, you will receive personal study-related medical care from the study doctor and regular follow up on your health to monitor the effectiveness of the care you will receive. The results of this research will be used to find out if the experimental medication being studied will be of benefit to others with hypertension at risk of cardiovascular events or not. Study volunteers are an important part of moving medical care forward.

Who may qualify

You may qualify if

Are 18 years or older for patients who have established cardiovascular disease (CVD), OR
Are 55 years or older with high risk for CVD
Have established CVD (defined as coronary, cerebrovascular, or peripheral artery disease) or high risk for CVD
Have been treated for hypertension on stable therapy with at least 2 standard of care antihypertensive medications, one of which must be a thiazide, thiazide-like, or loop diuretic

This study may not be a fit if

Have a known history of secondary hypertension
Have symptomatic orthostatic hypotension
Have alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3×upper limit of normal (ULN)
Have total serum bilirubin >1.5×ULN at screening
Have an international normalized ratio (INR) >1.5 at screening
Have serum potassium >4.8 mEq/L at screening
Have an estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m^2

Every study has additional criteria the research site will review with you.

Participants who qualify for this study will receive a study-related health examination at no cost, as well as possible compensation for time and travel.

What participation may involve

Regular visits with the study team at no cost
Study assessments and health monitoring throughout
Check-ins between visits
Informed consent before anything begins — questions welcome

Time commitment: ≈5 years — confirmed by the research site. The full visit schedule is explained during informed consent.

What participants may receive

Study-related care from a physician-led team
Study assessments at no cost
Reimbursement for reasonable travel, where applicable

Specifics vary by study and site, and are never a guarantee of benefit. Being in a study is not a substitute for regular medical care.

Participating research sites

Where this study is enrolling

SARNIA, ONBluewater Clinical Research GroupPrincipal investigator: Dr. John O’Mahony, Dr. Sean PetersonView site →

MONTREAL, QCTHEO Médical - SalaberryPrincipal investigator: Dr. Maria ValoisView site →

Learn more

About the condition

Cardiovascular disease

Cardiovascular disease is a group of conditions affecting the heart and the blood vessels that carry blood around your body. The most common form in Canada is ischemic…

Learn about this condition →

About the condition

Hypertension (high blood pressure)

Blood pressure is the force of blood pushing against the walls of your arteries. Hypertension, or high blood pressure, means that force stays higher than it should over…

Learn about this condition →

Other studies you can explore

All current studies →

RecruitingStudy of Orforglipron in Participants With Peripheral Artery DiseaseMontrealCheck availability →

RecruitingA Study for Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney DiseaseSarnia · MontrealCheck availability →

Enrolment closedStudy in Participants With Chronic Kidney Disease and High Blood PressureStouffvilleView study →

Common questions

Do I have to decide now?

No. Answering the questions is not a commitment — it simply lets the research team see whether this study may be appropriate and contact you to talk it through.

Will it cost me anything?

No. Study visits and study assessments are provided at no cost, and reasonable travel may be reimbursed where applicable.

What happens after I submit the form?

A member of the research team reviews your answers and contacts you — usually within two business days — to answer questions and review the next steps.

Could I receive a placebo?

Some studies compare a treatment with a placebo. Whether this study does is explained clearly during informed consent, before you decide anything.

Can I leave the study after it starts?

Yes. Participation is always voluntary. You can withdraw at any time without giving a reason and without it affecting your regular medical care.

Request contact

Ask the research site to contact you

Your answers go only to the research site, help the team prepare before they call — and completing the form doesn’t obligate you to take part.

JAS Study Interest (Stream A)

See if you may qualify

A few quick questions — about a minute. Your answers help the research team prepare before they contact you.

Who may take part in this study?

Myself

Someone I care for

Age of the person who may take part

For anyone under 18, a parent or legal guardian should complete this form and would need to consent on their behalf.

Has a doctor diagnosed you (or the person who may take part) with the condition this study is about?

Yes

Not sure

Postal code (first 3 characters are enough)

Hypertension Study for Subjects With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease