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Medical condition

Trigeminal Neuralgia

Plain-language information about trigeminal neuralgia, and what clinical research is asking about it.
Plain-language guide, not medical advice
Reading time3 min
In CanadaNo Canadian figure published
Studies recruitingNone right now

Trigeminal neuralgia is a facial pain condition. The trigeminal nerve carries sensation from your face, and when it misfires the result is sudden, brief, electric-shock-like pain, almost always on one side. A light touch, cold air or chewing can set it off.

By the numbers in Canada
45 in 100,000people worldwide are living with trigeminal neuralgia in a given year, according to a 2026 review of eight decades of international data. This is not a Canadian figure: no Canadian prevalence or incidence figure for trigeminal neuralgia has been published.
Source: Journal of Clinical Neurology, systematic review and meta-regression of 17 studies in 12 countries, 1945 to 2024, 2026
  • The same 2026 review found about 25 new cases per 100,000 person-years, and a lifetime prevalence of 108 in 100,000. New cases were about twice as common in females, at 43.84 per 100,000 person-years against 21.85 in males. None of the 17 studies were Canadian. Source: Journal of Clinical Neurology, 2026
  • Canada has a national patient organisation for the condition. The Trigeminal Neuralgia Association of Canada, founded in 2000 by a person living with trigeminal neuralgia, describes itself as the only registered charity in Canada focused on supporting people who live with it, and offers one to one support alongside funding Canadian research. Source: Trigeminal Neuralgia Association of Canada, 2026
  • Procedures for trigeminal neuralgia are done in Canada. University Health Network in Toronto runs a Gamma Knife Centre that treats the condition, and Migraine Canada notes that an MRI is often ordered to look for nerve compression but very often comes back normal. Source: University Health Network and Migraine Canada, 2026

What trigeminal neuralgia is, and what it is not

It is not a toothache, though it is often mistaken for one, and some people have dental treatment before the real cause is found. The pain is usually felt in the cheek, mouth or gum, so teeth get the blame.

It is also not imagined. There is usually a physical explanation: Migraine Canada lists a blood vessel loop pressing on the nerve, a tumour, multiple sclerosis and past viral infection among the causes.

Signs and symptoms

  • Sudden, brief, stabbing or electric-shock-like pain on one side of the face
  • Pain starting near the mouth and shooting towards the ear, eye or nostril
  • Attacks set off by touch, speaking, chewing or cold air, or by nothing obvious
  • Bouts of frequent attacks separated by spells with no pain at all
  • Over time, more frequent attacks and a dull ache in between

The pattern varies between people, and can change over the years.

A woman standing outdoors beside raised garden beds on a bright day, one hand resting on her shoulder.
Attacks are often set off by ordinary things: a cold draught, chewing, or a hand brushing the face. Illustrative photograph.

What raises the risk

Some things cannot be changed:

  • Age. Migraine Canada says it mainly affects people over 50
  • Being female. In a 2026 international review, new cases were about twice as common in females
  • A blood vessel loop lying against the nerve, a tumour pressing on it, or damage from multiple sclerosis

Little here is about lifestyle. What can often be worked on, with a health care team, is narrower:

  • Finding a secondary cause, since MS, a tumour or vascular compression change what is offered
  • Planning around known triggers: cold air, touch, chewing and dental appointments

How trigeminal neuralgia is diagnosed in Canada

Migraine Canada describes this as a clinical diagnosis, based on how you describe the pain and on a neurological examination. Your clinician will ask what triggers attacks and whether there are pain-free spells, and will check facial sensation, jaw strength and eye movements. Dental causes are usually considered first. An MRI is commonly ordered to look for a vessel pressing on the nerve, MS or a tumour, and Migraine Canada notes the scan very often comes back normal, which does not mean the pain is not real. Referral to a neurologist, pain clinic or neurosurgeon follows if a procedure is considered.

Treatment and day-to-day management

Care usually starts with medicine and moves to procedures if pain persists. A health care team may discuss:

  • Anticonvulsant medicines first: Migraine Canada names carbamazepine, oxcarbazepine, gabapentin, pregabalin, phenytoin and lamotrigine
  • Baclofen, a muscle relaxant, and nerve blocks or botulinum toxin injections
  • Microvascular decompression, the operation used when a vessel is pressing on the nerve
  • Radiosurgery, such as the Gamma Knife treatment at University Health Network in Toronto, and rhizotomy

Which route fits, and when, is a decision for you and your own clinician.

When to talk to a doctor

  • Call 911 for sudden weakness or numbness on one side, a drooping face, trouble speaking or a sudden vision change. These are stroke signs, not trigeminal neuralgia.
  • Seek urgent care for facial pain with fever, jaw swelling or a discharging tooth, which point to infection, and for a painful red eye with blurred vision.
  • Contact your provider promptly if you cannot eat or drink because of the pain, or if you develop facial numbness rather than only pain, since that points to a cause needing investigation.

Why clinical research matters for trigeminal neuralgia

The basic numbers are missing. No Canadian prevalence figure has been published, and the best global estimate comes from a 2026 review of 17 studies going back to 1945 in 12 countries, landing on an annual prevalence between 15 and 134 per 100,000. Diagnosis is often slow, since facial pain is easily blamed on teeth and the MRI is frequently normal. The mainstay medicines were developed for epilepsy, and access to surgery is concentrated in a few Canadian centres. Research is looking at better diagnosis, at medicines designed for this nerve pain, and at who benefits from which procedure.

Studies are how those questions get answered. Taking part is voluntary, informed consent comes first, and you can stop at any time without affecting your regular care. No one can say whether a study will help you personally.

Learn more from Canadian sources

Where this information comes from (5 sources)
  1. Journal of Clinical Neurology, Global Incidence and Prevalence of Trigeminal Neuralgia, 1945 to 2024, 2026
  2. Migraine Canada, Trigeminal neuralgia, 2026
  3. HealthLink BC, Trigeminal neuralgia, 2026
  4. Trigeminal Neuralgia Association of Canada, 2026
  5. University Health Network, Gamma Knife Centre, 2026

This page is written in plain language for people considering clinical research. It is general health information, not medical advice, and it does not replace a conversation with your own doctor or nurse practitioner.

Common questions

How common is trigeminal neuralgia?

There is no Canadian figure. The best available estimate is international: a 2026 systematic review in the Journal of Clinical Neurology pooled 17 studies from 12 countries covering 1945 to 2024 and found an annual prevalence of about 45 per 100,000 people, a lifetime prevalence of about 108 per 100,000, and about 25 new cases per 100,000 person-years. New cases were roughly twice as common in females. None of the studies were Canadian, so these figures describe the condition internationally rather than in Canada.

Why did my MRI come back normal if the pain is real?

A normal MRI is common in trigeminal neuralgia. Migraine Canada states that an MRI may be done to look for nerve compression but very often comes back normal, and that the diagnosis is clinical, based on how you describe the pain and on a neurological examination. The scan is looking for specific things: a blood vessel pressing on the nerve, changes from multiple sclerosis, or a tumour. Not finding one of those does not change the diagnosis, though it can affect which treatments are considered.

Is trigeminal neuralgia a dental problem?

No, although it is often mistaken for one. The pain is usually felt in the cheek, mouth or gum, so many people see a dentist first and some have dental treatment before the cause is identified. The pain comes from the trigeminal nerve, which carries sensation from the face. Dental causes are still worth ruling out, because tooth and jaw infections cause facial pain too and need different treatment, which is why facial pain with fever, swelling or a discharging tooth should be assessed promptly.

What to do next
  1. Talk to your doctor. This guide is information, not medical advice.
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