RecruitingHeadaches & Migraines · Pain
A Study for the Prevention of Episodic or Chronic Migraine in Adults
Sarnia, Ontario
Migraine is a neurological condition, not just a bad headache. An attack usually brings moderate to severe head pain along with nausea and sensitivity to light, sound or smell, and it can last from a few hours to a few days. Tension-type headache, cluster headache and medication-overuse headache are separate conditions with their own patterns, and telling them apart is what shapes the care you are offered.
In migraine, the brain’s pain and sensory processing is temporarily disrupted. That is why an attack so often arrives with nausea and a need for a dark, quiet room, why some people notice warning signs such as yawning, food cravings, neck stiffness or mood changes in the hours beforehand, and why a day of feeling drained and foggy can follow. The World Health Organization ranks migraine as the third highest cause of disability-adjusted life years worldwide.
Tension-type headache feels different: a steady, band-like pressure on both sides of the head, without the nausea and without pain that worsens sharply when you move. Cluster headache is different again. Medication-overuse headache can develop when acute headache treatments are taken on many days each month over a long period, and the World Health Organization describes it as the most common secondary headache disorder, affecting up to 5% of some populations. This is why clinicians pay more attention to the pattern of your headaches over weeks than to how bad any single one was.
Attack frequency varies widely, from a few times a year to most days of the month, and the pattern can change over a lifetime, particularly around hormonal changes.

Some risk factors cannot be changed:
Others can often be worked on, usually with support from a health care team:
Migraine is diagnosed clinically, usually by a family doctor or nurse practitioner, based on the pattern of your attacks rather than a scan or blood test. Your clinician will ask how often headaches happen, how long they last, what the pain is like, what comes with it, and what makes it better or worse. A headache diary, or a questionnaire such as the MIDAS or HIT-6, is often used to track frequency and impact over time. Imaging is generally reserved for people whose headaches have warning features or an unusual pattern, and some people are referred to a neurologist or a headache clinic.
Clinical research for Migraines and Headaches is enrolling. See the current studies
Care usually has two halves: something to take during an attack, and, for people with frequent attacks, something taken regularly to make attacks less frequent. Depending on your pattern and your other health conditions, a health care team may discuss:
Which preventive suits a given person is not predictable in advance, and finding a workable plan often takes more than one attempt. These are decisions for you and your own clinician rather than something this page can settle.
Migraine is common and disabling, yet many people in Canada wait years for a diagnosis, and access to headache specialists and to newer preventive treatments varies by province and by drug plan. Researchers still cannot predict which preventive treatment will work for a given person, and a meaningful share of people do not respond well to the options available. Trials under way include newer CGRP-targeting and other mechanism-specific medicines for both acute treatment and prevention, neuromodulation devices, treatments for cluster headache and medication-overuse headache, digital cognitive behavioural therapy and behavioural programs, and studies in groups that have been under-represented in past research.
Clinical studies are how those questions get settled. Most ask you to keep a headache diary for a period before and during the trial. Taking part is voluntary, you give informed consent before anything begins, and you can stop at any time without affecting the care you get from your own doctor. No one can say in advance whether a study will help you personally.
This page is written in plain language for people considering clinical research. It is general health information, not medical advice, and it does not replace a conversation with your own doctor or nurse practitioner.
No. Migraine is a neurological condition in which the brain's pain and sensory processing is temporarily disrupted, which is why attacks often bring nausea and sensitivity to light and sound as well as head pain. Many people also have warning symptoms before an attack and feel drained for a day afterward. The World Health Organization ranks migraine as the third highest cause of disability-adjusted life years worldwide.
Yes, this is recognised as medication-overuse headache, and the World Health Organization describes it as the most common secondary headache disorder, affecting up to 5% of some populations. It can develop when acute headache treatments are taken on many days each month over a long period. If you are reaching for acute treatment frequently, tell your health care provider, since the plan usually needs to be reviewed rather than simply continued.
Trials recruit across the spectrum, from people with a few attacks a month to people with chronic migraine of 15 or more headache days a month, and some focus on people who have not done well on previous preventives. Studies typically ask you to keep a headache diary for a period before and during the trial. Taking part is voluntary, requires informed consent, and you can stop at any time.
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