RecruitingOsteoarthritis · Overweight and Obesity
Study for People With Excess Body Weight and Knee Osteoarthritis
Montreal, Quebec
Low back pain is pain felt between the bottom of your ribs and the top of your legs. In about 9 out of 10 cases no specific structural cause is found, which is why clinicians often call it non-specific low back pain. Most episodes settle over a few weeks, but for many people the pain returns or carries on for months.
For most people, low back pain is not a sign of a damaged or crumbling spine. The World Health Organization reports that about 90% of cases have no identifiable structural cause. Scans often show worn discs and joints that are common with age and do not explain the pain, which is one reason Ontario Health advises imaging only when specific warning signs are present.
It is also not usually something to wait out lying down. Canadian guidance points the other way: staying as active as you reasonably can, with adjustments while symptoms settle, is part of standard care. Recurrence is normal rather than a sign of failure, and about 40% of Canadian adults have another episode within a year of the first. Pain that runs down a leg with numbness or weakness, or that follows a specific injury, is assessed differently, and related pain is covered on our pages for peripheral neuropathic pain and soft tissue injury.
The pattern varies widely. Some people have one episode and no more, others have flares that come and go for years, and the amount of pain does not track neatly with what a scan shows.

Some risk factors cannot be changed:
Others can often be worked on, usually with support from a health care team:
Most low back pain is assessed by a family doctor, nurse practitioner, physiotherapist or chiropractor without any scan. The clinician takes a history and does a physical examination, and screens for warning signs that could point to a serious cause such as nerve compression, infection, fracture, cancer or inflammatory arthritis. Ontario Health’s quality standard states that imaging such as X-ray, CT or MRI should be used only when those warning signs are present, because scans often show changes that are common with age and do not explain the pain. Imaging is nonetheless rising in Ontario, from 12.4% of people scanned within 180 days of a first low back pain visit in 2019 to 2020, to 16.8% in 2024 to 2025.
Clinical research for Back Pain is enrolling. See the current studies
Care is aimed at easing pain, keeping you moving and getting you back to the things you normally do. Depending on your symptoms and what a clinician finds, a health care team may discuss:
Opioids for chronic non-cancer back pain are addressed in Canada by the 2024 Canadian Opioid Prescribing Guideline, which frames them as a shared decision reached after other options have been considered. Which of these fits you depends on your own examination, your work and your other health conditions, and those are decisions for you and your own clinician.
Because most low back pain has no identifiable structural cause, researchers still cannot reliably tell who will recover in weeks and who will go on to months or years of pain, and there is no way to match a person to the treatment most likely to help them. Trials under way are testing non-opioid pain medicines and drugs aimed at specific pain-signalling pathways, exercise and psychological programs delivered digitally or by video, spinal cord stimulation and other neuromodulation devices, and stratified care models that sort people by their risk of a poor recovery. Others are examining how to reduce unnecessary imaging and how to support people to stay at or return to work.
Clinical studies are how those questions get answered. Taking part is voluntary, you give informed consent before anything begins, and you can stop at any time without affecting the care you get from your own doctor. Joining a study does not mean giving up your current treatment, and no one can say in advance whether a study will help you personally.
This page is written in plain language for people considering clinical research. It is general health information, not medical advice, and it does not replace a conversation with your own doctor or nurse practitioner.
Usually not. Ontario Health's quality standard says imaging should be ordered only when there are warning signs of a serious cause, because scans often show age-related changes that do not explain the pain and can lead to more tests. Your clinician will screen you for those warning signs and explain why a scan is or is not needed in your situation.
Canadian guidance points the other way. Staying as active as you reasonably can, with modifications while symptoms settle, is part of standard care, and a physiotherapist can help you find a level of movement that works. Talk with your health care provider about a plan that fits your pain, your job and any other health conditions.
Often yes. Many studies specifically recruit people with long-lasting or recurring low back pain, since that group has the greatest unmet need. Each study has its own eligibility rules about how long you have had pain, what treatments you have tried and what other conditions you live with, and a research team will check those with you before you decide.
RecruitingOsteoarthritis · Overweight and Obesity
Montreal, Quebec
RecruitingOsteoarthritis · Overweight and Obesity
Toronto & Stouffville, Ontario
Recruiting
RecruitingOsteoarthritis · Overweight and Obesity
Ontario · British Columbia
RecruitingHeadaches & Migraines · Pain
Sarnia, Ontario
RecruitingHeadaches & Migraines · Pain
Sarnia, Ontario