RecruitingOsteoarthritis · Overweight and Obesity
Study for People With Excess Body Weight and Knee Osteoarthritis
Montreal, Quebec
Soft tissue injuries affect the muscles, ligaments and tendons rather than the bones. A strain is a stretched or torn muscle or tendon, and a sprain is a stretched or torn ligament, the tough band that holds bones together at a joint. They can happen in a moment, with a fall or a twisted ankle, or build up slowly from repeated movement at work, at home or in sport.
These injuries are not fractures, but that does not make them minor. A badly sprained ankle can keep you off your feet longer than a small break, and a torn tendon may need surgical repair. Most soft tissue injuries do not need a scan: Canadian clinicians use validated decision rules, based on where you are tender and whether you can bear weight, to work out whether an X-ray is needed to rule out a fracture.
They are also not always sudden. Tendon problems in particular tend to build gradually as load outpaces what the tissue is used to, which is why they often appear after a change in work, training or activity rather than after an accident. Recovery is not uniformly quick either, and among Canadians aged 65 and older injured in a fall, sprains or strains were the second most common injury at 27%, after fractures at 39%. Pain from a fresh injury is covered further on our page for acute pain, and injuries to the lower back on our page for low back pain.
Two people with what looks like the same injury can recover on very different timelines, and swelling often lingers after the pain has largely settled.

Some risk factors cannot be changed:
Others can often be worked on, usually with support from a health care team:
Most soft tissue injuries are assessed by a family doctor, nurse practitioner, physiotherapist, chiropractor or emergency department clinician, based on how the injury happened and a physical examination of the area. Clinicians check for swelling, tenderness, joint stability, strength and range of movement, and apply validated rules to decide whether an X-ray is needed to rule out a fracture. Ultrasound or MRI is generally reserved for injuries that are not improving as expected, or where a significant tear or another diagnosis is suspected.
Most of the work of recovery happens outside a clinic, through what you do with the injured area over the following weeks. Depending on the tissue involved and how severe the injury is, a health care team may discuss:
How quickly to load an injured tendon or ligament, and whether a procedure adds anything, depends on the specific injury and on you. Those are decisions for you and your own clinician rather than something this page can settle.
Recovery varies a great deal between people, and researchers still cannot reliably predict who will heal quickly and who will have pain or reduced function months later, particularly with tendon problems and ankle, shoulder and hamstring injuries. There is also genuine debate about how much rest compared with early loading helps, and about which injections and procedures add value. Trials under way are testing exercise and loading protocols, injectable and biologic treatments, non-opioid pain medicines, fall prevention programs for older adults, and rehabilitation delivered remotely by app or video.
Studies in this area often recruit soon after an injury, because that is when early treatments are tested, while others recruit people whose symptoms have lasted longer. Taking part is voluntary, you give informed consent before anything begins, and you can stop at any time without affecting the care you get from your own clinician. No one can say in advance whether a study will help you personally.
This page is written in plain language for people considering clinical research. It is general health information, not medical advice, and it does not replace a conversation with your own doctor or nurse practitioner.
A sprain involves a ligament, the band of tissue that connects bone to bone at a joint, and a twisted ankle is the classic example. A strain involves a muscle or a tendon, the cord that attaches muscle to bone, such as a pulled hamstring. Both cause pain and swelling, and both are assessed in a similar way.
Often not. Canadian clinicians use validated decision rules that look at where you are tender and whether you can bear weight to decide whether an X-ray is needed to rule out a fracture. If those criteria are not met, imaging usually adds little. Your clinician will explain the reasoning for your specific injury.
Some studies specifically recruit people soon after an injury, because that is when treatments for swelling, pain and early rehabilitation are tested. Others recruit people whose symptoms have lasted longer. Each study sets its own window and eligibility rules, and a research team will review them with you and take your informed consent before you take part.
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