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Human Papilloma Virus (HPV) Vaccine

Plain-language information about HPV in Canada, the cancers it is linked to, and the research under way.
Plain-language guide, not medical advice
Reading time3 min
In Canada75% of sexually active Canadians
Studies recruitingNone right now

Human papillomavirus, or HPV, is a group of very common viruses passed on by skin-to-skin sexual contact. Most infections cause no symptoms and clear within about two years. A few persist, and those can lead to cancer years later.

By the numbers in Canada
75%of sexually active Canadians are estimated to have an HPV infection at some point in their lives if they are not immunised, which makes HPV the most common sexually transmitted infection in Canada.
Source: Canadian Immunization Guide, human papillomavirus vaccines chapter, 2024
  • PHAC attributes nearly 100% of cervical cancers, about 90% of anal cancers, 60% to 73% of throat (oropharyngeal) cancers, 40% to 50% of penile cancers and 40% of vaginal and vulvar cancers to HPV. Types 16 and 18 account for about 70% of cervical cancers worldwide, while the low-risk types 6 and 11 cause more than 90% of anogenital warts. Source: Public Health Agency of Canada, 2026
  • The Canadian Cancer Society estimates that 1,700 women in Canada will be diagnosed with cervical cancer in 2026 and that 450 will die from it. PHAC reported an estimated 1,550 new cases and 400 deaths for 2023, an incidence of about 8 cases per 100,000 women. Source: Canadian Cancer Society, 2026
  • School-based HPV immunisation programmes run in grades 4 to 7 across provinces and territories. They began in 2007 for girls and were extended to boys by 2017. Coverage among 14-year-olds in 2021 was about 84% for at least one dose, against a national target of 90% by age 17, and it varies greatly by province, territory and region. Source: Canadian Partnership Against Cancer, 2024
Worldwide660,000 new cases of cervical cancer and around 350,000 deaths were recorded worldwide in 2022, according to the World Health Organization, which also attributes 620,000 new cancer cases in women and 70,000 in men to HPV in 2019. These are international figures, not Canadian ones.Source: World Health Organization, human papillomavirus and cancer fact sheet, 2024

What HPV is, and what it is not

HPV is not rare, and it is not a mark against anyone. The Canadian Immunization Guide estimates 75% of sexually active Canadians would have an HPV infection at some point if not immunised, making it the most common sexually transmitted infection in Canada.

It is also not fast-moving. The Public Health Agency of Canada notes that where a high-risk type persists, progression to invasive cancer usually takes 15 to 20 years or longer. That gap is what lets cervical screening find changes well before cancer develops.

Signs and symptoms

  • Usually nothing at all, which is why most people never know they have it
  • Anogenital warts, which PHAC describes as skin-coloured, brown or pink
  • An abnormal cervical screening result, often the first sign a high-risk type has persisted
  • A persistent sore throat, hoarseness, difficulty swallowing or a neck lump
  • Anal bleeding, pain, itching or a lump

Because HPV is usually silent, screening matters more than waiting for symptoms.

A young adult in a bright clinic room with a sleeve rolled up, one hand resting over the upper arm.
HPV immunisation in Canada is delivered mainly through school-based programmes in grades 4 to 7. Illustrative photograph.

What raises the risk

Some risk factors cannot be changed:

  • HPV is very common, so ordinary sexual contact is the main exposure
  • Having a cervix, where most HPV-related cancers in women occur
  • A weakened immune system, including HIV, which the World Health Organization links to infections that persist

Others can often be worked on, usually with support from a health care team:

  • Immunisation status, which depends on the programme where you live
  • Attending cervical screening when eligible, since that is how persistent infection and precancerous change are found
  • The number of sexual partners you and your partners have had

How HPV is diagnosed in Canada

HPV itself is not routinely tested for outside cervical screening. Screening uses either an HPV test for high-risk types or a Pap test for cell changes, depending on your province or territory. An abnormal result leads to a repeat test or a colposcopy, where the cervix is examined closely and a tissue sample may be taken. Warts are diagnosed by how they look. There is no routine screening in Canada for HPV-related cancers of the throat, anus, penis, vagina or vulva.

Treatment and day-to-day management

Nothing treats the virus itself, so care targets what HPV causes. A health care team may discuss:

  • Anogenital warts: topical treatments, freezing or removal, with the understanding they can return
  • Precancerous cervical changes: repeat screening for lower-grade changes, or removal of the affected tissue for higher-grade changes
  • Cancer: treatment through provincial cancer programmes
  • Immunisation. Two HPV vaccines are authorised in Canada: the nonavalent Gardasil 9 and the bivalent Cervarix. NACI recommends the nonavalent vaccine as it covers the most HPV types, and in July 2024 described one dose for ages 9 to 20, two for 21 to 26, two with shared decision-making from 27, and three for people who are immunocompromised. What is publicly funded is set by each province and territory

What suits one person will not suit another. These are decisions for you and your own clinician.

When to talk to a doctor

  • See a health care provider promptly for bleeding between periods, after sex or after menopause, or new discharge or pelvic pain.
  • See a health care provider for a sore throat, hoarseness, difficulty swallowing or a neck lump lasting more than three weeks.
  • Book cervical screening when you are due, and follow up on any abnormal result.

Why clinical research matters for HPV

Canadian HPV research is now mostly about delivery and about the cancers screening does not cover. How long single-dose protection lasts is still being followed. Coverage is the other problem: the Canadian Partnership Against Cancer reports about 84% coverage for at least one dose among 14-year-olds in 2021 against a 90% target, varying widely between provinces. The Canadian Cancer Society reported in November 2025 that progress toward eliminating cervical cancer in Canada has stalled. Research areas include self-collection for screening, therapeutic vaccines, and whether screening is feasible for throat and anal cancers.

Taking part is voluntary. You give informed consent first, and you can stop at any time without affecting the care you get from your own doctor. No one can say in advance whether a study will help you personally.

Learn more from Canadian sources

Where this information comes from (6 sources)
  1. Canadian Immunization Guide, human papillomavirus vaccines chapter, 2024
  2. Public Health Agency of Canada, human papillomavirus (HPV): for health professionals, 2026
  3. NACI, summary of statement of July 24, 2024: updated recommendations on human papillomavirus vaccines, 2024
  4. Canadian Cancer Society, cervical cancer statistics, 2026
  5. Canadian Partnership Against Cancer, HPV vaccine delivery, 2024
  6. World Health Organization, human papillomavirus and cancer fact sheet, 2024

This page is written in plain language for people considering clinical research. It is general health information, not medical advice, and it does not replace a conversation with your own doctor or nurse practitioner.

Common questions

What does NACI recommend about HPV vaccination?

In its statement of July 2024, the National Advisory Committee on Immunization continued to strongly recommend HPV vaccination for everyone aged 9 to 26, and recommended using the nonavalent vaccine because it covers the greatest number of HPV types. It described one dose for people aged 9 to 20, with a two-dose schedule as an individual option, two doses for people aged 21 to 26, and two doses through shared decision-making with a health care provider for people 27 and older. A three-dose schedule continues to be recommended for people who are immunocompromised or living with HIV. NACI advises, but each province and territory decides what its programme funds and for whom, and those rules change.

Is HPV vaccination free in Canada?

Publicly funded school-based programmes exist in every province and territory, delivered in grades 4 to 7 according to the Canadian Partnership Against Cancer, and they cover all genders. Beyond the school programme it varies: some provinces run catch-up programmes, and Manitoba, Prince Edward Island and Newfoundland and Labrador have once-eligible-always-eligible policies. The Canadian Cancer Society notes that vaccination is recommended for people aged 9 to 45, but a recommendation and public funding are not the same thing. Check the immunisation page for your province or territory, or ask a pharmacist.

If I have had HPV, does that mean I will get cancer?

Almost certainly not. The Public Health Agency of Canada notes that most HPV infections clear on their own within about two years without treatment. Where a high-risk type does persist, progression to invasive cancer typically takes 15 to 20 years or longer, which is what makes cervical screening effective at finding changes long before cancer develops. HPV is common enough that the Canadian Immunization Guide estimates three quarters of sexually active Canadians would have it at some point without immunisation, while cervical cancer is estimated to affect 1,700 people in Canada in 2026.

What to do next
  1. Talk to your doctor. This guide is information, not medical advice.
  2. Check for a match. Find your study match
  3. Not ready yet? Join the community and we will write to you when something opens.
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