25 studies recruiting now13 research sites across CanadaJoin the community
Home/Conditions/Soft Tissue Injury (muscles ligaments tendons)
Medical condition

Soft Tissue Injury (muscles ligaments tendons)

Plain-language information about sprains, strains and tendon injuries in Canada, and the research enrolling for them now.
Plain-language guide, not medical advice
Reading time5 min
In Canada2 million+ injury ED visits a year
Studies recruiting5 now enrolling

Soft tissue injuries affect the muscles, ligaments and tendons rather than the bones. A strain is a stretched or torn muscle or tendon, and a sprain is a stretched or torn ligament, the tough band that holds bones together at a joint. They can happen in a moment, with a fall or a twisted ankle, or build up slowly from repeated movement at work, at home or in sport.

By the numbers in Canada
2 million+emergency department visits across Canada each year are due to injuries, and about 291,000 people were admitted to hospital for an injury in 2024 to 2025.
Source: Canadian Institute for Health Information, 2026
  • Among Canadians aged 65 and older who were injured in a fall, sprains or strains were the second most common injury at 27%, after fractures at 39%. In 2017 to 2018, 5.8% of Canadians aged 65 and older living at home, about 350,000 people, reported a fall injury in the previous 12 months. Source: Public Health Agency of Canada, 2024
  • Fall injuries are becoming more common and more costly in Canada. Fall-related hospitalizations rose from 49,152 in 2008 to 2009 to 72,392 in 2019 to 2020, and the direct health care cost of injurious falls among older Canadian adults was estimated at 5.6 billion dollars in 2018. Source: Public Health Agency of Canada, 2024
  • Pain-related disability is the most common type of disability in Canada. In 2022, 27% of Canadians aged 15 and older, or 8.0 million people, reported a disability, and 62% of them reported a pain-related disability, ahead of flexibility at 40% and mobility at 39%. Source: Statistics Canada, Canadian Survey on Disability, 2023
Worldwide10% of all years lived with disability worldwide are accounted for by injuries and violence. Injuries cause about 4.4 million deaths a year, nearly 8% of all deaths, and falls alone cause more than 684,000 of them.Source: World Health Organization, 2024

What a soft tissue injury is, and what it is not

These injuries are not fractures, but that does not make them minor. A badly sprained ankle can keep you off your feet longer than a small break, and a torn tendon may need surgical repair. Most soft tissue injuries do not need a scan: Canadian clinicians use validated decision rules, based on where you are tender and whether you can bear weight, to work out whether an X-ray is needed to rule out a fracture.

They are also not always sudden. Tendon problems in particular tend to build gradually as load outpaces what the tissue is used to, which is why they often appear after a change in work, training or activity rather than after an accident. Recovery is not uniformly quick either, and among Canadians aged 65 and older injured in a fall, sprains or strains were the second most common injury at 27%, after fractures at 39%. Pain from a fresh injury is covered further on our page for acute pain, and injuries to the lower back on our page for low back pain.

Signs and symptoms

  • Pain that starts at the time of the injury, or builds up over days of repeated activity
  • Swelling and bruising around the injured muscle, tendon or joint
  • Tenderness when you press on the sore spot
  • Trouble putting weight on the area, or a joint that feels loose or unstable
  • Stiffness, or a reduced range of movement
  • Muscle weakness or spasm near the injury
  • A popping or tearing sensation at the moment of injury in more severe tears

Two people with what looks like the same injury can recover on very different timelines, and swelling often lingers after the pain has largely settled.

A woman standing outdoors beside raised garden beds on a bright day, one hand resting on her shoulder.
Progressive strengthening and a gradual return to movement are central to soft tissue injury care in Canada. Illustrative photograph.

What raises the risk

Some risk factors cannot be changed:

  • Getting older, since tendons and ligaments become less elastic and falls become more common
  • A previous sprain, strain or tendon injury in the same area
  • Some medical conditions and medicines that affect tendon and muscle health

Others can often be worked on, usually with support from a health care team:

  • Work or sport involving repeated lifting, reaching, twisting or overhead movement
  • Sudden increases in activity, training load or workload without a gradual build-up
  • Low muscle strength, poor balance and fatigue
  • Home and workplace fall hazards such as loose rugs, poor lighting, clutter and unsafe footwear

How soft tissue injuries are diagnosed in Canada

Most soft tissue injuries are assessed by a family doctor, nurse practitioner, physiotherapist, chiropractor or emergency department clinician, based on how the injury happened and a physical examination of the area. Clinicians check for swelling, tenderness, joint stability, strength and range of movement, and apply validated rules to decide whether an X-ray is needed to rule out a fracture. Ultrasound or MRI is generally reserved for injuries that are not improving as expected, or where a significant tear or another diagnosis is suspected.

Treatment and day-to-day management

Clinical research for Soft Tissue Injury (muscles ligaments tendons) is enrolling. See the current studies

Most of the work of recovery happens outside a clinic, through what you do with the injured area over the following weeks. Depending on the tissue involved and how severe the injury is, a health care team may discuss:

  • Early self-care such as protection, relative rest, ice or heat, compression and elevation, followed by a gradual return to movement
  • Physiotherapy and structured exercise therapy, including progressive strengthening, balance work and load management for tendon problems
  • Non-opioid pain medicines chosen with a clinician, including acetaminophen and topical or oral anti-inflammatory medicines
  • Braces, taping, splints, orthotics and walking aids, plus occupational therapy and workplace or activity modification during recovery
  • Procedures and surgery for selected injuries, such as injections or repair of a complete tendon or ligament tear, usually after assessment by a specialist

How quickly to load an injured tendon or ligament, and whether a procedure adds anything, depends on the specific injury and on you. Those are decisions for you and your own clinician rather than something this page can settle.

When to talk to a doctor

  • Call 911 or go to an emergency department for a limb that looks deformed or bent the wrong way, for heavy bleeding, for numbness or a limb that is pale or cold, or after a serious fall, crash or blow to the head.
  • Seek same-day care if you cannot bear any weight on the injured leg or cannot move the joint at all, if you heard or felt a pop with immediate severe swelling, or if the area becomes hot, red and increasingly painful with a fever, which can signal infection.
  • Book an appointment if pain, swelling or weakness is not improving after two to three weeks, or if a joint keeps giving way, since ongoing instability may need further assessment.

Why clinical research matters for soft tissue injuries

Recovery varies a great deal between people, and researchers still cannot reliably predict who will heal quickly and who will have pain or reduced function months later, particularly with tendon problems and ankle, shoulder and hamstring injuries. There is also genuine debate about how much rest compared with early loading helps, and about which injections and procedures add value. Trials under way are testing exercise and loading protocols, injectable and biologic treatments, non-opioid pain medicines, fall prevention programs for older adults, and rehabilitation delivered remotely by app or video.

Studies in this area often recruit soon after an injury, because that is when early treatments are tested, while others recruit people whose symptoms have lasted longer. Taking part is voluntary, you give informed consent before anything begins, and you can stop at any time without affecting the care you get from your own clinician. No one can say in advance whether a study will help you personally.

Learn more from Canadian sources

Where this information comes from (4 sources)
  1. Canadian Institute for Health Information, Injury and trauma emergency department and hospitalization statistics, 2026
  2. Public Health Agency of Canada, Surveillance report on falls among older adults in Canada, 2024
  3. Statistics Canada, Canadian Survey on Disability, 2022, 2023
  4. World Health Organization, Injuries and violence fact sheet, 2024

This page is written in plain language for people considering clinical research. It is general health information, not medical advice, and it does not replace a conversation with your own doctor or nurse practitioner.

Common questions

What is the difference between a sprain and a strain?

A sprain involves a ligament, the band of tissue that connects bone to bone at a joint, and a twisted ankle is the classic example. A strain involves a muscle or a tendon, the cord that attaches muscle to bone, such as a pulled hamstring. Both cause pain and swelling, and both are assessed in a similar way.

Do I need an X-ray after a sprain?

Often not. Canadian clinicians use validated decision rules that look at where you are tender and whether you can bear weight to decide whether an X-ray is needed to rule out a fracture. If those criteria are not met, imaging usually adds little. Your clinician will explain the reasoning for your specific injury.

Can I take part in a study while I am still recovering from an injury?

Some studies specifically recruit people soon after an injury, because that is when treatments for swelling, pain and early rehabilitation are tested. Others recruit people whose symptoms have lasted longer. Each study sets its own window and eligibility rules, and a research team will review them with you and take your informed consent before you take part.

What to do next
  1. Talk to your doctor. This guide is information, not medical advice.
  2. See the current studies. 6 studies for Soft Tissue Injury (muscles ligaments tendons)
  3. Not ready yet? Join the community and we will write to you when something opens.
Research studies

Studies for Soft Tissue Injury (muscles ligaments tendons)

See all Soft Tissue Injury (muscles ligaments tendons) trials →

Learn more about Soft Tissue Injury (muscles ligaments tendons)

Health blog →

Connecting Canadians with clinical research studies conducted by a network of physicians committed to advancing medicine — since 1995.

JoinAStudy.ca provides information about clinical research and does not provide medical advice, diagnosis, or treatment. Only a qualified study doctor can determine your eligibility for a study. Participation is always voluntary.

© 2026 JoinAStudy.ca · A network of Canadian physicians.|Designed by Pixelore.ca