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Home/Current studies/A Study for Intermittent Prevention of Menstrual Migraine
Recruiting now

A Study for Intermittent Prevention of Menstrual Migraine

Enrolling at: Sarnia
Phase 3Study phase
≈5 monthsStudy length
18–45Age range
1 siteResearch locations

About this study

Do you suffer from pain caused by Menstrual Migraines?

This clinical research study is looking at the safety and effectiveness of an investigational medication option for preventing menstruation related migraine headaches.

The purpose of this study is to evaluate the efficacy and safety of rimegepant when administered during the peri-menstrual period (PMP) for intermittent prevention of migraine in women who experience menstrual migraine attacks.

Would you like to take part?

As a volunteer in a research study, you will receive study-related medical care from the study doctor and regular follow up of your condition to monitor the safety and effectiveness of the care you will receive. Study volunteers are an important part of moving medical care forward.

Who may qualify

You may qualify if
  • Have regular menstrual cycles between ≥24 days and ≤34 days
  • Have a minimum 1-year history of migraine (with or without aura) consistent with a diagnosis according to the International Classification of Headache Disorders, 3rd Edition
  • Have a history of menstrual migraine attacks of at least 3 months
  • Have a reported history of experiencing at least 1 migraine attack during the perimenstrual period in at least 2 out of 3 menstrual cycles immediately prior to screening.
  • Are receiving a permitted background continuous prophylactic migraine medication, the medication dose must be stable for at least 3 months prior to the Screening visit and, the dose is not expected to change during the course of the study
This study may not be a fit if
  • Have greater than 6 migraine days per month that are outside of the perimenstrual period in the 3 months prior to Screening
  • Have a diagnosis of chronic migraine or a history of more than 14 headache days per month on average, in the 3 months prior to Screening
  • Have a history of retinal migraine, basilar migraine or hemiplegic migraine
  • Have a current diagnosis of schizophrenia, bipolar, or borderline personality disorder
  • Experience other pain syndromes (eg, fibromyalgia, complex regional pain syndrome), or significant neurological disorders (other than migraine), or other medical conditions (including endocrine and gynecological eg, severe dysmenorrhea
Every study has additional criteria the research site will review with you.

What participation may involve

  • Regular visits with the study team at no cost
  • Study assessments and health monitoring throughout
  • Check-ins between visits
  • Informed consent before anything begins — questions welcome
Time commitment: ≈5 months — confirmed by the research site. The full visit schedule is explained during informed consent.

What participants may receive

  • Study-related care from a physician-led team
  • Study assessments at no cost
  • Reimbursement for reasonable travel, where applicable
Specifics vary by study and site, and are never a guarantee of benefit. Being in a study is not a substitute for regular medical care.
Participating research sites

Where this study is enrolling

SARNIA, ONBluewater Clinical Research GroupPrincipal investigator: Dr. John O’Mahony, Dr. Sean PetersonView site →

Learn more

About the condition

Migraines and Headaches

Migraine is a neurological condition, not just a bad headache. An attack usually brings moderate to severe head pain along with nausea and sensitivity to light, sound or…

Learn about this condition →
About the condition

Arthritis & Chronic Pain

Arthritis is not one condition but a group of more than 100, all affecting joints and the tissues around them. Chronic pain means pain that lasts longer than…

Learn about this condition →
About the condition

Women’s Health

Women's health covers conditions that affect only people with female reproductive anatomy, conditions that affect women more often or differently, and the care built around periods, contraception and…

Learn about this condition →
Related reading
Arthritis & Joint PainAutoimmune Disease FAQRead →Arthritis & Joint PainA Guide to Autoimmune Disease Research in 2026Read →AnemiaNeurological and Blood Autoimmune DiseasesRead →

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Common questions

Do I have to decide now?
No. Answering the questions is not a commitment — it simply lets the research team see whether this study may be appropriate and contact you to talk it through.
Will it cost me anything?
No. Study visits and study assessments are provided at no cost, and reasonable travel may be reimbursed where applicable.
What happens after I submit the form?
A member of the research team reviews your answers and contacts you — usually within two business days — to answer questions and review the next steps.
Could I receive a placebo?
Some studies compare a treatment with a placebo. Whether this study does is explained clearly during informed consent, before you decide anything.
Can I leave the study after it starts?
Yes. Participation is always voluntary. You can withdraw at any time without giving a reason and without it affecting your regular medical care.
Request contact

Ask the research site to contact you

Your answers go only to the research site, help the team prepare before they call — and completing the form doesn’t obligate you to take part.
JAS Study Interest (Stream A)

See if you may qualify

A few quick questions — about a minute. Your answers help the research team prepare before they contact you.

For anyone under 18, a parent or legal guardian should complete this form and would need to consent on their behalf.

See if you may qualify →

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