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Home/Current studies/Study on Major Cardiovascular Events in Adults With…
Recruiting now

Study on Major Cardiovascular Events in Adults With Elevated Lipoprotein

Enrolling at: Sarnia · Hamilton
Phase 3Study phase
≈5.5 yearsStudy length
18+Age range
2 sitesResearch locations

About this study

Do you have elevated lipoprotein levels and suffer from cardiovascular disease?

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.

Would you like to take part? Would you like a friend or family member to take part?

As a volunteer in a research study, you will receive personal study-related medical care from the study doctor and regular follow up on your health to monitor the effectiveness of the care you will receive. The results of this research will be used to find out if the experimental medication being studied will be of benefit to others with elevated lipoprotein levels and cardiovascular disease or not. Study volunteers are an important part of moving medical care forward.

Who may qualify

You may qualify if
  • Have Lp(a) ≥175 nanomoles per liter (nmol/L)
  • Meet one of the following criteria:
    • Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening
    • Are at risk for a first ASCVD event, defined as one or more of the following:
      • Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event
      • A high coronary artery calcium (CAC) score
      • Reduced kidney function with diabetes
      • Combination(s) of high risk factors
This study may not be a fit if
  • Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between screening and randomization
  • Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study
  • Have uncontrolled high blood pressure
  • Have New York Heart Association (NYHA) class III or IV heart failure
  • Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study
  • Have severe kidney impairment
  • Have had cancer within 5 years prior to screening
Every study has additional criteria the research site will review with you.

Participants who qualify for this study will receive a study-related health examination at no cost, as well as possible compensation for time and travel.

What participation may involve

  • Regular visits with the study team at no cost
  • Study assessments and health monitoring throughout
  • Check-ins between visits
  • Informed consent before anything begins — questions welcome
Time commitment: ≈5.5 years — confirmed by the research site. The full visit schedule is explained during informed consent.

What participants may receive

  • Study-related care from a physician-led team
  • Study assessments at no cost
  • Reimbursement for reasonable travel, where applicable
Specifics vary by study and site, and are never a guarantee of benefit. Being in a study is not a substitute for regular medical care.
Participating research sites

Where this study is enrolling

SARNIA, ONBluewater Clinical Research GroupPrincipal investigator: Dr. John O’Mahony, Dr. Sean PetersonView site →HAMILTON, ONWinterberry Family MedicinePrincipal investigator: Dr. Steven V. ZizzoView site →

Learn more

About the condition

Cardiovascular disease

Cardiovascular disease is a group of conditions affecting the heart and the blood vessels that carry blood around your body. The most common form in Canada is ischemic…

Learn about this condition →
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Common questions

Do I have to decide now?
No. Answering the questions is not a commitment — it simply lets the research team see whether this study may be appropriate and contact you to talk it through.
Will it cost me anything?
No. Study visits and study assessments are provided at no cost, and reasonable travel may be reimbursed where applicable.
What happens after I submit the form?
A member of the research team reviews your answers and contacts you — usually within two business days — to answer questions and review the next steps.
Could I receive a placebo?
Some studies compare a treatment with a placebo. Whether this study does is explained clearly during informed consent, before you decide anything.
Can I leave the study after it starts?
Yes. Participation is always voluntary. You can withdraw at any time without giving a reason and without it affecting your regular medical care.
Request contact

Ask the research site to contact you

Your answers go only to the research site, help the team prepare before they call — and completing the form doesn’t obligate you to take part.
JAS Study Interest (Stream A)

See if you may qualify

A few quick questions — about a minute. Your answers help the research team prepare before they contact you.

For anyone under 18, a parent or legal guardian should complete this form and would need to consent on their behalf.

See if you may qualify →

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