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Home/Current studies/Study for Participants With Type 2 Diabetes on…
Recruiting now

Study for Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

Enrolling at: Sarnia · Hamilton
Phase 2Study phase
18–75Age range
2 sitesResearch locations

About this study

Do you have type 2 diabetes and are currently taking Semaglutide or Tirzepatide to control your glucose levels?

This clinical research study is evaluating an experimental treatment for type 2 diabetics.

The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with the experimental medication compared with placebo in participants with type 2 diabetes who are not at their HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.

Would you like to take part?

As a volunteer in a research study, you’ll receive study-related medical care from the study doctor and regular follow-up of your health to monitor the effectiveness of the care you’ll receive. The results of this research will be used to find out if the investigational medication being studied will be of benefit to others struggling to manage type 2 diabetes, and whether it will be made widely available to all Canadians. Study volunteers are an important part of moving medical care forward.

Who may qualify

You may qualify if
  • Have type 2 diabetes
  • Have HbA1c ≥7.5% to ≤10.5% at screening
  • Have a body mass index (BMI) of ≥27 kilograms per square meter (kg/m2) at screening
  • Have had a stable body weight for the three months prior to screening
  • Are on a stable treatment dose of one of the following incretins for at least three months:
    • Injectable semaglutide (1 and 2 milligram (mg))
    • Injectable tirzepatide (5, 7.5, 10, 12.5 and 15 mg
This study may not be a fit if
  • Have type 1 diabetes, latent autoimmune diabetes, or history of ketoacidosis or hyperosmolar coma
  • Have a prior or planned surgical treatment for obesity
  • Have any of the following cardiovascular conditions within three months prior to screening:
    • acute myocardial infarction
    • cerebrovascular accident (stroke)
    • unstable angina, or
    • hospitalization due to congestive heart failure
  • Have used insulin to control blood glucose within the past year (short-term use allowed)
  • Any current use of another oral antihyperglycemic medication (OAM) (including but not limited to, Dipeptidyl Peptidase IV Inhibitors (DPP-4i) and meglitinides) may be randomized if the additional OAM treatment was discontinued at least 3 months prior to screening
    • If participant has been on stable doses (for at least three months) of up to three OAMs (limited to metformin, sodium-glucose cotransporter-2 (SGLT2) inhibitors, alpha-glucosidase inhibitors, sulfonylurea, and/or thiazolidinediones (TZD), they are permitted to participate in the study
  • Have taken any medications or alternative remedies for weight loss within three months prior to screening
Every study has additional criteria the research site will review with you.

What participation may involve

  • Regular visits with the study team at no cost
  • Study assessments and health monitoring throughout
  • Check-ins between visits
  • Informed consent before anything begins — questions welcome

What participants may receive

  • Study-related care from a physician-led team
  • Study assessments at no cost
  • Reimbursement for reasonable travel, where applicable
Specifics vary by study and site, and are never a guarantee of benefit. Being in a study is not a substitute for regular medical care.
Participating research sites

Where this study is enrolling

SARNIA, ONBluewater Clinical Research GroupPrincipal investigator: Dr. John O’Mahony, Dr. Sean PetersonView site →HAMILTON, ONWinterberry Family MedicinePrincipal investigator: Dr. Steven V. ZizzoView site →

Learn more

About the condition

Diabetes

Diabetes means the level of sugar, or glucose, in your blood stays too high because your body cannot make enough insulin or cannot use the insulin it makes.…

Learn about this condition →
Related reading
Alzheimer’s & DementiaPreventive Medicine: Extending Health Span, Not Just LifespanRead →Alzheimer’s & DementiaLongevity Drugs: From Diabetes Treatments to Anti-Aging ResearchRead →CardiovascularMetabolism, Fasting & Longevity PathwaysRead →

Other studies you can explore

All current studies →
RecruitingA Study of Eloralintide in Participants With Obesity, or Overweight Without Type 2 DiabetesSarnia · HamiltonCheck availability →Enrolment closedWeight Management Study in Individuals With Obesity and Type 2 DiabetesLondonView study →RecruitingA Research Study of Insulin Icodec in Adults With Type 2 DiabetesMontrealCheck availability →

Common questions

Do I have to decide now?
No. Answering the questions is not a commitment — it simply lets the research team see whether this study may be appropriate and contact you to talk it through.
Will it cost me anything?
No. Study visits and study assessments are provided at no cost, and reasonable travel may be reimbursed where applicable.
What happens after I submit the form?
A member of the research team reviews your answers and contacts you — usually within two business days — to answer questions and review the next steps.
Could I receive a placebo?
Some studies compare a treatment with a placebo. Whether this study does is explained clearly during informed consent, before you decide anything.
Can I leave the study after it starts?
Yes. Participation is always voluntary. You can withdraw at any time without giving a reason and without it affecting your regular medical care.
Request contact

Ask the research site to contact you

Your answers go only to the research site, help the team prepare before they call — and completing the form doesn’t obligate you to take part.
JAS Study Interest (Stream A)

See if you may qualify

A few quick questions — about a minute. Your answers help the research team prepare before they contact you.

For anyone under 18, a parent or legal guardian should complete this form and would need to consent on their behalf.

See if you may qualify →

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